Effects of alendronate on post-traumatic osteoarthritis induced by anterior cruciate ligament rupture in mice.
Khorasani MS, Diko S, Hsia AW, Anderson MJ, Genetos DC, Haudenschild DR and Christiansen BA. Arthritis Res and Therapy. 2015. [Epub Ahead of Print].
Take Home Message: In a mouse model, high-dose injections of alendronate delayed joint damage compared with a low-dose or placebo.
Post-traumatic osteoarthritis (PTOA) is a common, long-term consequence of anterior cruciate ligament (ACL) injury. Unfortunately, there is no approved therapy to prevent or slow the onset of PTOA. Bisphosphonates, like alendronate, are typically used to treat osteoporosis but may also be beneficial in delaying PTOA; however, this is not proven. Therefore, Khorasani and colleagues completed a study to better understand the effectiveness of alendronate in mice with or without an ACL rupture.