National Institute of Neurological Disorders and Stroke Consensus Diagnostic Criteria for Traumatic Encephalopathy Syndrome
Katz DI, Bernick C, Dodick DW, Mez J, Mariani ML, Adler CH, Alosco ML, Balcer LJ, Banks SJ, Barr WB, Brody DL, Cantu RC, Dams-O’Connor K, Geda YE, Jordan BD, McAllister TW, Peskind ER, Petersen RC, Wethe JV, Zafonte RD, Foley ÉM, Babcock DJ, Koroshetz WJ, Tripodis Y, McKee AC, Shenton ME, Cummings JL, Reiman EM, Stern RA. Neurology. 2021 Mar 15:10.1212/WNL.0000000000011850. doi: 10.1212/WNL.0000000000011850. Epub ahead of print. PMID: 33722990.
The Diagnostics, Imaging, and Genetics Network for the Objective Study and Evaluation of Chronic Traumatic Encephalopathy (DIAGNOSE CTE) Research Project held the first National Institute of Neurological Disorders and Stroke (NINDS) Consensus Workshop to Define the Diagnostic Criteria for Traumatic Encephalopathy Syndrome in 2019. Traumatic encephalopathy syndrome is the clinical syndrome associated with chronic traumatic encephalopathy (CTE). The meeting included a multidisciplinary panel of 20 clinician-scientists. The recommendations cover various aspects of the primary diagnostic criteria: 1) substantial exposure to repetitive head impacts, 2) clinical features (e.g., cognitive impairment), 3) ruling out other disorders, and 4) level of functional dependence/dementia. The authors also discuss how to determine the level of certainty for CTE pathology.